Health supplement — not for medicinal use. For adults.
1. Description
Renostead is an antioxidant supplement that combines N-Acetylcysteine and Taurine.
N-Acetylcysteine: N-Acetylcysteine (also known as N-acetyl-L-cysteine or NAC) is a derivative of cysteine with an acetyl group attached to the amino group of cysteine. NAC is essentially a prodrug that is converted to cysteine (in the intestine by the enzyme aminoacylase) and absorbed in the intestine into the blood stream. Cysteine is a key constituent to glutathione and hence administration of acetylcysteine replenishes glutathione stores.
Taurine: Taurine is a type of conditionally essential amino acid found throughout the body. It is particularly concentrated in the brain, eyes, heart and muscles. It comprises of over 50% of the total free amino acid pool of the heart. Taurine has antioxidant properties and supports endothelial cell function.
2. Composition
Each tablet of Renostead contains N-acetylcysteine 150 mg and Taurine 500 mg
3. Dosage Form
Tablet
4. Pharmacology
Pharmacodynamics
Renostead combines N-acetylcysteine (NAC) and taurine, which act together as antioxidants and may help reduce oxidative stress and support endothelial function.
N-Acetylcysteine (NAC)
NAC is a precursor of L-cysteine, which is required for the synthesis of glutathione (GSH), one of the body’s major endogenous antioxidants.
It replenishes intracellular glutathione stores, scavenges reactive oxygen species (ROS), and reduces oxidative stress.
Taurine
Taurine is a sulfur-containing amino acid with antioxidant, anti-inflammatory, and cytoprotective properties.
It helps stabilise cell membranes, improves endothelial function, and regulates intracellular calcium homeostasis.
Pharmacokinetics
Absorption
N-Acetylcysteine is rapidly absorbed after oral administration. Due to first-pass metabolism, its oral bioavailability is approximately 4–10%, with peak plasma concentrations occurring within 1–2 hours.
Taurine is readily absorbed from the gastrointestinal tract, with peak plasma concentrations generally achieved within 1–2 hours after oral administration.
Distribution
NAC is widely distributed throughout body tissues and is deacetylated intracellularly to L-cysteine, where it contributes to glutathione synthesis.
Taurine is extensively distributed, with high concentrations found in the kidneys, heart, skeletal muscle, retina, and central nervous system.
Metabolism
N-Acetylcysteine is metabolized primarily in the intestinal mucosa and liver to L-cysteine, which is utilized for glutathione synthesis and other sulfur-containing compounds.
Taurine undergoes minimal metabolism and participates directly in physiological processes such as osmoregulation, membrane stabilization, bile acid conjugation, and antioxidant defense.
Elimination
NAC and its metabolites are eliminated primarily through the kidneys, with metabolites excreted in the urine.
Taurine is excreted mainly in the urine, although a significant proportion is reabsorbed by the renal tubules to maintain physiological homeostasis.
5. Intended use
Antioxidant supplement providing N-acetylcysteine and taurine to support the body’s antioxidant defences, as advised by the physician.
6. Contraindications
- Known hypersensitivity to N-acetylcysteine, taurine or any component of the formulation.
- History of bronchospasm or anaphylactoid reaction to acetylcysteine.
7. Precautions
- Use with caution in patients with active or past peptic ulcer and in asthmatic patients.
- Pregnancy and lactation: use only if clearly needed, on the physician’s advice.
- This product is not intended to diagnose, treat, cure or prevent any disease.
8. Drug Interactions
- Nitroglycerin: concomitant use may cause hypotension and headache.
- Activated charcoal may reduce the absorption of N-acetylcysteine.
- Oral antibiotics: separate doses by at least 2 hours.
9. Adverse Effects
Generally well tolerated. Nausea, vomiting, dyspepsia, abdominal discomfort and diarrhoea may occur; rash, pruritus or other hypersensitivity reactions are rare.
10. Dosage & Administration
The optimal daily dose of Renostead is 1 tablet twice daily after meals.
11. Overdosage
No data available.
12. Storage
Keep in dry place at a temperature not exceeding 30°C. Protect from light.
13. Presentation
10 tablets in a strip, 10 strips in a Box.